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Human CD162 Protein, mFc Tag

Human CD162 Protein, mFc Tag

产品编号

KMP2634

别名

选择素 P 配体, Human CD162 Protein, mFc Tag, CD162

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias选择素 P 配体, Human CD162 Protein, mFc Tag, CD162
Catalog NumberKMP2634
Product DescriptionThe Human CD162 Protein(KMP2634) is produced in HEK293 Cells. The target gene encoding the human SELPLG (AAC50061.1) (Met1-Val295) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular NameCD162
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>90% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundP-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein, expressed on leukocytes and platelets as a homodimer of two disulfide-linked subunits of ~12 kD. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 protein requires two distinct posttranslational modifications for the Ca2+-dependent recognition by the lectin domain of P-selectin, that is tyrosine sulfation and specific O-linked glycosylation (sialic acid and fucose). PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight55.4 kDa

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