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Human OX40 Protein, His Tag

Human OX40 Protein, His Tag

产品编号

KMP2630

别名

肿瘤坏死因子受体超家族成员4, Human OX40 Protein, His Tag, OX40

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias肿瘤坏死因子受体超家族成员4, Human OX40 Protein, His Tag, OX40
Catalog NumberKMP2630
Product DescriptionThe Human OX40 Protein(KMP2630) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Ala216) of human TNFRSF4 (NP_003318.1) is expressed, fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular NameOX40
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>80% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundOX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight21.7 kDa

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