Human OX40 Protein, His Tag
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产品编号
KMP2630
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别名
肿瘤坏死因子受体超家族成员4, Human OX40 Protein, His Tag, OX40
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规格
- 50ug
- 100ug
- 200ug
Alias | 肿瘤坏死因子受体超家族成员4, Human OX40 Protein, His Tag, OX40 |
Catalog Number | KMP2630 |
Product Description | The Human OX40 Protein(KMP2630) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Ala216) of human TNFRSF4 (NP_003318.1) is expressed, fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
Molecular Name | OX40 |
Species | Human |
Host | HEK293 Cells |
Size | 50ug, 100ug, 200ug |
Purity | >80% as determined by SDS-PAGE |
Purification | Affinity purification |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Formulation | PBS, pH7.4 |
Background | OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease. |
Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
Molecular Weight | 21.7 kDa |