Human MCP-4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human MCP-4 Protein, His Tag

Human MCP-4 Protein, His Tag

产品编号

KMP2624

别名

单核细胞趋化蛋白 MCP-4, Human MCP-4 Protein, His Tag, MCP-4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	单核细胞趋化蛋白 MCP-4, Human MCP-4 Protein, His Tag, MCP-4
Catalog Number	KMP2624
Product Description	The Human MCP-4 Protein(KMP2624) is produced in Yeast. The target gene encoding human CCL13 (NP_005399.1) (Gln24-Thr98) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	MCP-4
Species	Human
Host	Yeast
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chemokines, CCL13 binds to several chemokine receptors (CCR1, CCR2 and CCR3), allowing it to elicit different effects on its target cells. A number of studies have shown that CCL13 is involved in many chronic inflammatory diseases, in which it functions as a pivotal molecule involved in the selective recruitment of cell lineages to the inflamed tissues and their subsequent activation. MCP-4/CCL13 is secreted from chondrocytes and activates the proliferation of rheumatoid synovial cells, thereby leading to joint destruction in RA. The interferon-gamma in combination with interleukin-1beta/tumor necrosis factor-alpha activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade. CCL13 may have some role in the pathogenesis of systemic sclerosis (SSc).
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	10 kDa

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