Human Frizzled 5 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human Frizzled 5 Protein, hFc Tag

Human Frizzled 5 Protein, hFc Tag

产品编号

KMP2622

别名

卷曲蛋白受体5, Human Frizzled 5 Protein, hFc Tag, Frizzled 5

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	卷曲蛋白受体5, Human Frizzled 5 Protein, hFc Tag, Frizzled 5
Catalog Number	KMP2622
Product Description	The Human Frizzled 5 Protein(KMP2622) is produced in HEK293 Cells. The target gene encoding the human FZD5 (NP_003459.2) (Met1-Pro167) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	Frizzled 5
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Wnt signaling is involved in a variety of embryonic development processes of nonvertebrates and vertebrates, where it determines cell motility, cell polarity, differentiation, proliferation and apoptosis, as well as formation of neural synapses. Various homologs of the Wingless protein, termed WNT factors, represent key mediators and act through a receptor complex comprised of members of the Frizzled and low density lipoprotein-related receptors (LRP). 19 WNTs, 1 Frizzled, and 2 LRP proteins have been identified. Frizzled is a family of G protein-coupled receptor proteins consisting of a divergent signal peptide, a highly conserved extracellular cysteine-rich domain (CRD), a variable-length linker region, a seven-pass transmembrane domain, and a variable-length C-terminal tail.Frizzled 5 (FZD5) is believed to be the receptor for the Wnt5A ligand, and also interactions with Wnt1B, Wnt2B, and Wnt 7A functionally. Recent studies of WNT5A/Frizzled-5 signaling have revealed an unexpected and novel role in orchestrating adaptive immunity in response to microbial stimulation. In addition, FZD5 is also implicated in the survival of mature neurons in the parafascicular nucleus of the thalamus.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	42.7 kDa

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