Human OSM Protein, His Tag_天津卡梅德科技发展有限公司

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Human OSM Protein, His Tag

Human OSM Protein, His Tag

产品编号

KMP2612

别名

肿瘤抑制因子, Human OSM Protein, His Tag, OSM

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤抑制因子, Human OSM Protein, His Tag, OSM
Catalog Number	KMP2612
Product Description	The Human OSM Protein(KMP2612) is produced in HEK293 Cells. The target gene encoding the mature form of human OSM (P13725) (Met 1-Arg 221) is expressed, fused with a polyhistidine tag at the C-terminus.
Molecular Name	OSM
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	23.6 kDa

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