Human TROP2 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human TROP2 Protein, His Tag, Avi Tag

Human TROP2 Protein, His Tag, Avi Tag

产品编号

KMP2603

别名

人滋养细胞表面抗原, Human TROP2 Protein, His Tag, Avi Tag, TROP2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	人滋养细胞表面抗原, Human TROP2 Protein, His Tag, Avi Tag, TROP2
Catalog Number	KMP2603
Product Description	The Human TROP2 Protein(KMP2603) is produced in HEK293 Cells. The target gene encoding the human TACSTD2 (NP_002344.2) (Met1-Thr274) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	TROP2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	25mM Sodium Citrate, 200mM NaCl, 0.02% Tween80, 10% Trehalose, pH6.0
Background	TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	31.14 kDa

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