Human IL-6R Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human IL-6R Protein, His Tag, Avi Tag

Human IL-6R Protein, His Tag, Avi Tag

产品编号

KMP2592

别名

白介素-6 受体, Human IL-6R Protein, His Tag, Avi Tag, IL-6R

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白介素-6 受体, Human IL-6R Protein, His Tag, Avi Tag, IL-6R
Catalog Number	KMP2592
Product Description	The Human IL-6R Protein(KMP2592) is produced in HEK293 Cells. The target gene encoding the human IL6R (NP_000556.1)(Met1-Pro365) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	IL-6R
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	41.80 kDa

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