Human TIM-3 Protein, hFc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human TIM-3 Protein, hFc Tag, Avi Tag

Human TIM-3 Protein, hFc Tag, Avi Tag

产品编号

KMP2588

别名

重组人T细胞免疫球蛋白黏蛋白3, Human TIM-3 Protein, hFc Tag, Avi Tag, TIM-3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	重组人T细胞免疫球蛋白黏蛋白3, Human TIM-3 Protein, hFc Tag, Avi Tag, TIM-3
Catalog Number	KMP2588
Product Description	The Human TIM-3 Protein(KMP2588) is produced in HEK293 Cells. The target gene encoding the human HAVCR2 (NP_116171.3)(Met1-Arg200) is expressed with a c-terminal Avi tagged Fc region of human IgG1 at the C-terminus (Fc-Avi). The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	TIM-3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	48.41 kDa

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