Human IL18BP Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human IL18BP Protein, hFc Tag

Human IL18BP Protein, hFc Tag

产品编号

KMP2571

别名

白介素18结合蛋白, Human IL18BP Protein, hFc Tag, IL18BP

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白介素18结合蛋白, Human IL18BP Protein, hFc Tag, IL18BP
Catalog Number	KMP2571
Product Description	The Human IL18BP Protein(KMP2571) is produced in HEK293 Cells. The target gene encoding the human IL18BP (AAD17187.1) (Met1-Gly192) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	IL18BP
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	44.4 kDa

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