Human ICAM-1 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human ICAM-1 Protein, His Tag, Avi Tag

Human ICAM-1 Protein, His Tag, Avi Tag

产品编号

KMP2565

别名

细胞间粘附分子-1, Human ICAM-1 Protein, His Tag, Avi Tag, ICAM-1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	细胞间粘附分子-1, Human ICAM-1 Protein, His Tag, Avi Tag, ICAM-1
Catalog Number	KMP2565
Product Description	The Human ICAM-1 Protein(KMP2565) is produced in HEK293 Cells. The target gene encoding the Human ICAM1 (NP_000192.2) (Met1-Glu480) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	ICAM-1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	52.77 kDa

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