Human HVEM Protein, His Tag_天津卡梅德科技发展有限公司

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Human HVEM Protein, His Tag

Human HVEM Protein, His Tag

产品编号

KMP2557

别名

疱疹病毒入侵介质蛋白, Human HVEM Protein, His Tag, HVEM

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	疱疹病毒入侵介质蛋白, Human HVEM Protein, His Tag, HVEM
Catalog Number	KMP2557
Product Description	The Human HVEM Protein(KMP2557) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Val202) of human HVEM (NP_003811.2) is expressed with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	HVEM
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	19 kDa

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