Human GFRA1 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human GFRA1 Protein, hFc Tag

Human GFRA1 Protein, hFc Tag

产品编号

KMP2555

别名

GDNF 家族受体α1, Human GFRA1 Protein, hFc Tag, GFRA1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	GDNF 家族受体α1, Human GFRA1 Protein, hFc Tag, GFRA1
Catalog Number	KMP2555
Product Description	The Human GFRA1 Protein(KMP2555) is produced in HEK293 Cells. The target gene encoding the human GFRA1 (NP_001138925.1) (Met1-Ser424) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	GFRA1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	50.8 kDa

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