Human PD-L2 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human PD-L2 Protein, hFc Tag

Human PD-L2 Protein, hFc Tag

产品编号

KMP2546

别名

程序性死亡配体2, Human PD-L2 Protein, hFc Tag, PD-L2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性死亡配体2, Human PD-L2 Protein, hFc Tag, PD-L2
Catalog Number	KMP2546
Product Description	The Human PD-L2 Protein(KMP2546) is produced in HEK293 Cells. The target gene encoding the human PDCD1LG2 (NP_079515.2) (Met1-Pro219) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	PD-L2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	49.3 kDa

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