Human Galectin-1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human Galectin-1 Protein, His Tag

Human Galectin-1 Protein, His Tag

产品编号

KMP2545

别名

半乳糖凝集素1, Human Galectin-1 Protein, His Tag, Galectin-1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	半乳糖凝集素1, Human Galectin-1 Protein, His Tag, Galectin-1
Catalog Number	KMP2545
Product Description	The Human Galectin-1 Protein(KMP2545) is produced in E. coli. The target gene encoding the Human LGALS1 (NP_002296.1) (Gln56-Leu279) is expressed, with a polyhistidine tag at the N-terminus.
Molecular Name	Galectin-1
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 10% Glycerol, pH7.4
Background	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumor growth has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation, and allergies as well as host-pathogen interactions.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	16.07 kDa

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