Human AXL Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human AXL Protein, mFc Tag

Human AXL Protein, mFc Tag

产品编号

KMP2542

别名

AXL 受体酪氨酸激酶, Human AXL Protein, mFc Tag, AXL

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	AXL 受体酪氨酸激酶, Human AXL Protein, mFc Tag, AXL
Catalog Number	KMP2542
Product Description	The Human AXL Protein(KMP2542) is produced in HEK293 Cells. The target gene encoding the human AXL (AAH32229.1) (Met1-Pro449) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	AXL
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	72.11 kDa

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