Human Osteoprotegerin Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human Osteoprotegerin Protein, hFc Tag

Human Osteoprotegerin Protein, hFc Tag

产品编号

KMP2540

别名

骨保护素, Human Osteoprotegerin Protein, hFc Tag, Osteoprotegerin

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	骨保护素, Human Osteoprotegerin Protein, hFc Tag, Osteoprotegerin
Catalog Number	KMP2540
Product Description	The Human Osteoprotegerin Protein(KMP2540) is produced in Insect Cells. The target gene encoding the human TNFRSF11B (NP_002537.3) (Met1-Leu401) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	Osteoprotegerin
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	100mM Glycerolcine, 10mM NaCl, pH7.0
Background	Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	70.3 kDa

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