Human CCN3 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CCN3 Protein, His Tag

Human CCN3 Protein, His Tag

产品编号

KMP2536

别名

过表达肾母细胞瘤, Human CCN3 Protein, His Tag, CCN3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	过表达肾母细胞瘤, Human CCN3 Protein, His Tag, CCN3
Catalog Number	KMP2536
Product Description	The Human CCN3 Protein(KMP2536) is produced in Insect Cells. The target gene encoding the full length of human NOV (NP_002505.1) (Met 1-Met 357) is expressed, fused with a polyhistidine tag at the C-terminus.
Molecular Name	CCN3
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 100mM NaCl, 0.5mM PMSF, 10mM Imidazole, 10% Glycerol, pH7.4
Background	Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix, and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development, and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signaling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of some cell lineages including hematopoietic, osteogenic, and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis, and a crucial component within the bone marrow microenvironment.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	37 kDa

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