Human METAP1 Protein, His Tag
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产品编号
KMP2533
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别名
甲硫氨酰氨肽酶 1, Human METAP1 Protein, His Tag, METAP1
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规格
- 50ug
- 100ug
- 200ug
产品中心
Alias | 甲硫氨酰氨肽酶 1, Human METAP1 Protein, His Tag, METAP1 |
Catalog Number | KMP2533 |
Product Description | The Human METAP1 Protein(KMP2533) is produced in Insect Cells. The target gene encoding the human METAP1 (NP_055958.2) (His52-Phe386) is expressed with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus. |
Molecular Name | METAP1 |
Species | Human |
Host | Insect Cells |
Size | 50ug, 100ug, 200ug |
Purity | >95% as determined by SDS-PAGE |
Purification | Affinity purification |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Formulation | 20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0 |
Background | Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. |
Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
Molecular Weight | 39.3 kDa |
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