Human LDLR Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human LDLR Protein, mFc Tag

Human LDLR Protein, mFc Tag

产品编号

KMP2526

别名

低密度脂蛋白受体, Human LDLR Protein, mFc Tag, LDLR

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	低密度脂蛋白受体, Human LDLR Protein, mFc Tag, LDLR
Catalog Number	KMP2526
Product Description	The Human LDLR Protein(KMP2526) is produced in HEK293 Cells. The target gene encoding the human LDLR (NP_000518.1) (Met1-Arg788) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	LDLR
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 100mM Glycerolcine, 10mM NaCl, pH8.0
Background	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low-density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	111.2 kDa

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