Human Dectin-1 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human Dectin-1 Protein, hFc Tag

Human Dectin-1 Protein, hFc Tag

产品编号

KMP2523

别名

Β葡聚糖受体抗体, Human Dectin-1 Protein, hFc Tag, Dectin-1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	Β葡聚糖受体抗体, Human Dectin-1 Protein, hFc Tag, Dectin-1
Catalog Number	KMP2523
Product Description	The Human Dectin-1 Protein(KMP2523) is produced in HEK293 Cells. The target gene encoding the human Dectin1 (NP_072092.2) (Thr 66- Met201) is expressed with the Fc region of human IgG1 at the N-terminus.
Molecular Name	Dectin-1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 5% Glycerol, pH7.4
Background	Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as hAving a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	42.1 kDa

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