Human E-Cadherin Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human E-Cadherin Protein, His Tag

Human E-Cadherin Protein, His Tag

产品编号

KMP2520

别名

上皮性钙黏附蛋白, Human E-Cadherin Protein, His Tag, E-Cadherin

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	上皮性钙黏附蛋白, Human E-Cadherin Protein, His Tag, E-Cadherin
Catalog Number	KMP2520
Product Description	The Human E-Cadherin Protein(KMP2520) is produced in HEK293 Cells. The target gene encoding the human CDH1 (NP_004351.1) (Asp155-Ala709) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	E-Cadherin
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	62 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0