Human ERBB3 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human ERBB3 Protein, hFc Tag

Human ERBB3 Protein, hFc Tag

产品编号

KMP2515

别名

受体酪氨酸蛋白激酶, Human ERBB3 Protein, hFc Tag, ERBB3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	受体酪氨酸蛋白激酶, Human ERBB3 Protein, hFc Tag, ERBB3
Catalog Number	KMP2515
Product Description	The Human ERBB3 Protein(KMP2515) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Thr643) of human ErbB3 (NP_001973.2) precursor is expressed with the C-terminal fused Fc region of human IgG1. The purified protein is biotinylated in vitro.
Molecular Name	ERBB3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	95.4 kDa

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