Human Bcl-2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human Bcl-2 Protein, His Tag

Human Bcl-2 Protein, His Tag

产品编号

KMP2514

别名

Bcl2 修饰因子, Human Bcl-2 Protein, His Tag, Bcl-2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	Bcl2 修饰因子, Human Bcl-2 Protein, His Tag, Bcl-2
Catalog Number	KMP2514
Product Description	The Human Bcl-2 Protein(KMP2514) is produced in E. coli. The target gene encoding the human BCL2 isoform 1 (NP_000624.2) (Met1-Asp211(G101V)) is expressed, with a polyHistide tag at the C-terminus.
Molecular Name	Bcl-2
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20% Glycerol, 100mM Arg, PBS, pH8.5
Background	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes. It is expressed in a variety of tissues. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	24.72 kDa

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