Human TLR3 Protein, His Tag_天津卡梅德科技发展有限公司

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Human TLR3 Protein, His Tag

Human TLR3 Protein, His Tag

产品编号

KMP2513

别名

Toll样受体3, Human TLR3 Protein, His Tag, TLR3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	Toll样受体3, Human TLR3 Protein, His Tag, TLR3
Catalog Number	KMP2513
Product Description	The Human TLR3 Protein(KMP2513) is produced in Insect Cells. The target gene encoding the Human TLR3 (AAH59372.1) (Lys27-Ser711) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	TLR3
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 300mM NaCl, 10% Glycerol, pH8.0
Background	Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR that is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	79.38 kDa

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