Human L1CAM Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human L1CAM Protein, hFc Tag

Human L1CAM Protein, hFc Tag

产品编号

KMP2498

别名

L1-细胞粘附分子, Human L1CAM Protein, hFc Tag, L1CAM

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	L1-细胞粘附分子, Human L1CAM Protein, hFc Tag, L1CAM
Catalog Number	KMP2498
Product Description	The Human L1CAM Protein(KMP2498) is produced in HEK293 Cells. The target gene encoding the Human L1CAM (NP_000416.1) (Met1-Glu1120) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	L1CAM
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	149.93 kDa

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