Human IL1RAP Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human IL1RAP Protein, hFc Tag

Human IL1RAP Protein, hFc Tag

产品编号

KMP2494

别名

白介素-1 受体辅助蛋白, Human IL1RAP Protein, hFc Tag, IL1RAP

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白介素-1 受体辅助蛋白, Human IL1RAP Protein, hFc Tag, IL1RAP
Catalog Number	KMP2494
Product Description	The Human IL1RAP Protein(KMP2494) is produced in HEK293 Cells. The target gene encoding the human IL1RAP (NP_002173.1) (Met1-Glu359) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	IL1RAP
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	65.8 kDa

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