Human p38 Protein, His Tag_天津卡梅德科技发展有限公司

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Human p38 Protein, His Tag

Human p38 Protein, His Tag

产品编号

KMP2473

别名

丝裂原活化蛋白激酶 14, Human p38 Protein, His Tag, p38

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	丝裂原活化蛋白激酶 14, Human p38 Protein, His Tag, p38
Catalog Number	KMP2473
Product Description	The Human p38 Protein(KMP2473) is produced in Insect Cells. The target gene encoding The amino acids cprresponding to the full length of human MAPK14 isoform 1 (NP_001306.1) (Met1-Ser360) is fused with a polyhistidine tag at the N-terminus. Activated in vitro by MAP2K6 (10422-H20B1).
Molecular Name	p38
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris-HCl, 150mM NaCl, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% Glycerol, pH7.5
Background	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with MAPK14. The substrates of p38 alpha include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of p38 alpha in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response. In response to activation by environmental stress, pro-inflammatory cytokines, and lipopolysaccharide, MAPK14 phosphorylates some transcription factors, such as ELK1 and ATF2, and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. MAPK14 plays a critical role in the production of some cytokines, for example, IL-6. It may play a role in the stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	43.7 kDa

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