Human BAFF Protein, Avi Tag, Fc Tag_天津卡梅德科技发展有限公司

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Human BAFF Protein, Avi Tag, Fc Tag

Human BAFF Protein, Avi Tag, Fc Tag

产品编号

KMP2469

别名

B细胞激活因子BAFF, Human BAFF Protein, Avi Tag, Fc Tag, BAFF

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	B细胞激活因子BAFF, Human BAFF Protein, Avi Tag, Fc Tag, BAFF
Catalog Number	KMP2469
Product Description	The Human BAFF Protein(KMP2469) is produced in HEK293 Cells. The target gene encoding the human TNFSF13B (NP_006564.1) (Ala134-Leu285) is expressed with a N-terminal Avi tag followed by a Fc region of human IgG1 tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed..
Molecular Name	BAFF
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors are a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS is an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	45.6 kDa

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