Human CD137 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD137 Protein, His Tag

Human CD137 Protein, His Tag

产品编号

KMP2462

别名

肿瘤坏死因子超家族成员9, Human CD137 Protein, His Tag, CD137

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子超家族成员9, Human CD137 Protein, His Tag, CD137
Catalog Number	KMP2462
Product Description	The Human CD137 Protein(KMP2462) is produced in HEK293 Cells. The target gene encoding the TNFRSF9 (NP_001552.2) (Met1-Gln186) is expressed with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	CD137
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS
Background	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	18.7 kDa

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