Human ERBB2 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human ERBB2 Protein, hFc Tag

Human ERBB2 Protein, hFc Tag

产品编号

KMP2437

别名

人类表皮生长因子受体2, Human ERBB2 Protein, hFc Tag, ERBB2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	人类表皮生长因子受体2, Human ERBB2 Protein, hFc Tag, ERBB2
Catalog Number	KMP2437
Product Description	The Human ERBB2 Protein(KMP2437) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Thr652) of human ErbB2 (NP_004439.2) is fused with the Fc region of human IgG1 at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	ERBB2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	96.1 kDa

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