Recombinant Human PDPN Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human PDPN Protein, His Tag

Recombinant Human PDPN Protein, His Tag

产品编号

KMH1535

别名

T1A, GP36, GP40, Gp38, OTS8, T1A2, TI1A, T1A 2, AGGRUS, HT1A 1, PA2.26, podoplanin

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	T1A, GP36, GP40, Gp38, OTS8, T1A2, TI1A, T1A 2, AGGRUS, HT1A 1, PA2.26, podoplanin
Catalog Number	KMH1535
Molecular Name	PDPN
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1-alpha (T1A), and aggrus, is a 36kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid precursor (NP_6465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 27-228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential O-linked glycosolation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47% aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of Podoplanin.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	11.99 kDa
Note	仅供科研使用

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