Recombinant Human LDLR Avitag Protein, AVI & His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Recombinant Human LDLR Avitag Protein, AVI & His Tag

Recombinant Human LDLR Avitag Protein, AVI & His Tag

产品编号

KMH1333

别名

FH, FHC, FHCL1, LDLCQ2, low density lipoprotein receptor

规格

50ug
100ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	FH, FHC, FHCL1, LDLCQ2, low density lipoprotein receptor
Catalog Number	KMH1333
Molecular Name	LDLR
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Low-Density Lipoprotein (LDL) Receptor, also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~84 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B1 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). [1] It belongs to the Low density lipoprotein receptor gene family.[2] LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~7% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol, if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.[3-4]
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	84.37 kDa
Note	仅供科研使用

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0