Recombinant Human IFN-gamma R1/IFNGR1 Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human IFN-gamma R1/IFNGR1 Protein, His Tag

Recombinant Human IFN-gamma R1/IFNGR1 Protein, His Tag

产品编号

KMH1250

别名

CD119, IFNGR, IMD27A, IMD27B, interferon gamma receptor 1

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	CD119, IFNGR, IMD27A, IMD27B, interferon gamma receptor 1
Catalog Number	KMH1250
Molecular Name	IFNGR1
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases (Jak1 and Jak2). Jak1 and Jak2 constitutively associate with IFNGR1 and IFNGR2, respectively. Binding of IFN-γ to IFNGR1 induces the rapid dimerization of IFNGR1 chains, thereby forming a site that is recognized by the extracellular domain of IFNGR2. The ligand-induced assembly of the complete receptor complex contains two IFNGR1 and two IFNGR2 subunits which bring into close juxtaposition the intracellular domains of these proteins together with the inactive Jak1 and Jak2 kinases that they associate with. In this complex, Jak1 and Jak2 transactivate one another and then phosphorylate IFNGR1, thereby forming a paired set of Stat1 docking sites on the ligated receptor.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	25.08 kDa
Note	仅供科研使用

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