Recombinant Human GDNF Protein, His & Fc Tag_天津卡梅德科技发展有限公司

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Recombinant Human GDNF Protein, His & Fc Tag

Recombinant Human GDNF Protein, His & Fc Tag

产品编号

KMH1155

别名

ATF, ATF1, ATF2, HSCR3, HFB1 GDNF, glial cell derived neurotrophic factor

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	ATF, ATF1, ATF2, HSCR3, HFB1 GDNF, glial cell derived neurotrophic factor
Catalog Number	KMH1155
Molecular Name	GDNF
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR α(α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 11) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	46.12 kDa
Note	仅供科研使用

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