Recombinant Human EPCR/PROCR Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human EPCR/PROCR Protein, His Tag

Recombinant Human EPCR/PROCR Protein, His Tag

产品编号

KMH1027

别名

CCCA, EPCR, CCD41, protein C receptor

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	CCCA, EPCR, CCD41, protein C receptor
Catalog Number	KMH1027
Molecular Name	PROCR
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Endothelial Protein C Receptor (EPCR) is a Vitamin Kdependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (ProteaseActivated Receptor 1) on endothelial cells and subsequent upregulation of Protein Cinduced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the ThrombinThrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	21.34 kDa
Note	仅供科研使用

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