Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag
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产品编号
MOP2075
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别名
B7h, GI50, GL50, B7 H2, LICOS, B7RP 1, GL50 B, ICOS L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, icos ligand
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规格
- 50ug
- 100ug
Alias | B7h, GI50, GL50, B7 H2, LICOS, B7RP 1, GL50 B, ICOS L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, icos ligand |
Catalog Number | MOP2075 |
Molecular Name | Icosl |
Species | Mouse |
Host | Mammalian cells |
Size | 50ug, 100ug |
Protein Family | Other protein |
Purity | ≥90% as determined by SDS-PAGE |
Purification | Affinity Purification |
Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
Formulation | PBS |
Background | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein. |
Storage Condition | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
Shipping Condition | This product is shipped on ice packs or dry ice. |
Molecular Weight | 25.63 kDa |
Note | 仅供科研使用 |