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Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag

Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag

产品编号

MOP2075

别名

B7h, GI50, GL50, B7 H2, LICOS, B7RP 1, GL50 B, ICOS L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, icos ligand

规格
  • 50ug
  • 100ug
产品介绍
AliasB7h, GI50, GL50, B7 H2, LICOS, B7RP 1, GL50 B, ICOS L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, icos ligand
Catalog NumberMOP2075
Molecular NameIcosl
SpeciesMouse
HostMammalian cells
Size50ug, 100ug
Protein FamilyOther protein
Purity≥90% as determined by SDS-PAGE
PurificationAffinity Purification
Endotoxin< 1.0 EU per ug of the protein as determined by the LAL method.
FormulationPBS
BackgroundInducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein.
Storage ConditionStore the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping ConditionThis product is shipped on ice packs or dry ice.
Molecular Weight25.63 kDa
Note仅供科研使用

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