Recombinant Human PCSK9 Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human PCSK9 Protein, His Tag

Recombinant Human PCSK9 Protein, His Tag

产品编号

KMH501

别名

FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC 1, HCHOLA3, proprotein convertase subtilisin/kexin type 9

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC 1, HCHOLA3, proprotein convertase subtilisin/kexin type 9
Catalog Number	KMH501
Molecular Name	PCSK9
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Antibody drug target protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	Supplied as solution form in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl./Lyophilized from 50 mM Tris-HCl, pH 7.5, 150 mM NaCl.
Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons.[1] Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).[2-3]
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	58.17 kDa
Note	仅供科研使用

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