Recombinant Human CD163/CD163 Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human CD163/CD163 Protein, His Tag

Recombinant Human CD163/CD163 Protein, His Tag

产品编号

KMH346

别名

M130, MM130, SCARI1, CD163 molecule

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	M130, MM130, SCARI1, CD163 molecule
Catalog Number	KMH346
Molecular Name	CD163
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	CD molecule
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	CD163 is an acute phase-regulated receptor which participates in the removal and endocytosis of hemoglobin/haptoglobin complexes by macrophages and thus keeps tissues from free hemoglobin-mediated oxidative damage. Furthermore, CD163 partakes in the uptake and recycling of iron, through endocytosis of hemoglobin/haptoglobin and ensuing breakdown of heme. In addition, CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent way. CD163 demonstrates greater affinity for complexes of hemoglobin and multimeric haptoglobin of HP-1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP-1S phenotype. Moreover, CD163 stimulates a cascade of intracellular signals which involves tyrosine kinase-dependent calcium recruitment, inositol triphosphate formation and secretion of IL-6 & CSF-1.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	110.55 kDa
Note	仅供科研使用

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