Recombinant Human CD117/KIT Protein, His Tag
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产品编号
KMH292
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别名
PBT, SCFR, C Kit, CD117, MASTC, KIT proto oncogene, receptor tyrosine kinase
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规格
- 50ug
- 100ug
Alias | PBT, SCFR, C Kit, CD117, MASTC, KIT proto oncogene, receptor tyrosine kinase |
Catalog Number | KMH292 |
Molecular Name | KIT |
Species | Human |
Host | Mammalian cells |
Size | 50ug, 100ug |
Protein Family | CD molecule |
Purity | ≥90% as determined by SDS-PAGE |
Purification | Affinity Purification |
Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
Formulation | PBS, pH7.5 |
Background | Stem cell factor receptor (SC R), also known as c-kit, has a molecular weight of 145 kDa as a mature protein and is a member of the type III receptor tyrosine kinase (RTK) family that includes platelet-derived growth factor (PDGF) receptors and the macrophage colony-stimulating factor 1 (CSF-1) (c-fms) receptor. SCFR is essential for the development of normal hematopoietic cells and plays an important role in the survival, proliferation, and differentiation of mast cells, melanocytes, and germ cells. SCF R contains five extracellular immunoglobulin-like (Ig) domains, a single juxtamembrane domain (JMD), a cytoplasmic tyrosine kinase domain, Binding of SCF R to its ligand (stem cell factor, SCF) induces receptor dimerization, trans autophosphorylation of the kinase domain, recruitment of signaling proteins via phosphotyrosine binding or Src homology 2 (SH2) domains. |
Storage Condition | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
Shipping Condition | This product is shipped on ice packs or dry ice. |
Molecular Weight | 56.76 kDa |
Note | 仅供科研使用 |