Mouse CD152 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse CD152 Protein, Fc Tag

Mouse CD152 Protein, Fc Tag

产品编号

KMP2426

别名

细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, CD152

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, CD152
Catalog Number	KMP2426
Product Description	The Mouse CD152 Protein(KMP2426) is produced in HEK293 Cells and the target gene encoding Ala37-Asp161 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD152
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
SDS-PAGE
Predicted Molecular Weight	13.74 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9Z1A8#structure

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