Human CD278 Protein, Fc Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human CD278 Protein, Fc Tag

Human CD278 Protein, Fc Tag

产品编号

KMP2410

别名

诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278
Catalog Number	KMP2410
Product Description	The Human CD278 Protein(KMP2410) is produced in HEK293 Cells and the target gene encoding Glu21-Phe141 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD278
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige
SDS-PAGE
Predicted Molecular Weight	13.75 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9Y6W8
References	1.Eur. J. Immunol. 30:3707-3717 (2000) 2.Nature 397:263-266 (1999)
Function	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0