Human CD276 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD276 Protein, His Tag

Human CD276 Protein, His Tag

产品编号

KMP2397

别名

共刺激分子蛋白, CD276 antigen, CD276, B7 homolog 3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	共刺激分子蛋白, CD276 antigen, CD276, B7 homolog 3
Catalog Number	KMP2397
Product Description	The Human CD276 Protein(KMP2397) is produced in HEK293 Cells and the target gene encoding Leu29-Thr461 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD276
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
Predicted Molecular Weight	47.35 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q5ZPR3
References	1.Nat. Immunol. 2:269-274 (2001) 2.Genomics 82:365-377 (2003) 3.J. Immunol. 172:2352-2359 (2004) 4.Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645 (2004) 5.Eur. J. Immunol. 35:428-438 (2005) 6.Am. J. Respir. Cell Mol. Biol. 33:280-289 (2005)
Function	May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

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