Human CD155 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD155 Protein, His Tag

Human CD155 Protein, His Tag

产品编号

KMP2393

别名

重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155
Catalog Number	KMP2393
Product Description	The Human CD155 Protein(KMP2393) is produced in HEK293 Cells and the target gene encoding Trp21-Asn343 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD155
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, pH7.4
Background	Poliovirus Receptor(PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like(Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus(PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms(α, β, γ, and δ) with identical extracellular domains.
SDS-PAGE
Predicted Molecular Weight	35.9 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q6DKI7
References	J. Exp. Med. 213:167-176 (2016)
Function	Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

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