| Alias | V 集免疫调节受体, Platelet receptor Gi24, Gi24 |
| Catalog Number | KMP2392 |
| Product Description | The Human Gi24 Protein(KMP2392) is produced in HEK293 Cells and the target gene encoding Phe33-Ala194 is expressed with a Fc tag at the C-terminus. |
| Molecular Name | Gi24 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively. |
| SDS-PAGE |  |
| Predicted Molecular Weight | 18.14 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | Q9H7M9 |
| References | 1.Cancer Sci. 101:2368-2374 (2010)
2.Cancer Res. 74:1924-1932 (2014) |
| Function | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993).
May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). |
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