Human CD48 Protein, Fc Tag, His Tag_天津卡梅德科技发展有限公司

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Human CD48 Protein, Fc Tag, His Tag

Human CD48 Protein, Fc Tag, His Tag

产品编号

KMP2386

别名

信号传导淋巴细胞活化分子2, SLAM Family Member 2, CD48

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	信号传导淋巴细胞活化分子2, SLAM Family Member 2, CD48
Catalog Number	KMP2386
Product Description	The Human CD48 Protein(KMP2386) is produced in HEK293 Cells and the target gene encoding Gln27-Ser220 is expressed with a Fc, 6His tag at the C-terminus.
Molecular Name	CD48
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, but does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cell activation. CD48 plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma.
SDS-PAGE
Predicted Molecular Weight	22 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P09326
References	1.Biochim. Biophys. Acta 1589:140-150 (2002) 2.J. Immunol. 182:7672-7680 (2009) 3.Open Biol. 6:0-0 (2016) 4.J. Exp. Med. 188:2083-2090 (1998)
Function	Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817).

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