Human CD28 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Human CD28 Protein, Fc Tag

Human CD28 Protein, Fc Tag

产品编号

KMP2380

别名

T细胞特异性表面糖蛋白CD28, CD28 molecule, Tp44

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T细胞特异性表面糖蛋白CD28, CD28 molecule, Tp44
Catalog Number	KMP2380
Product Description	The Human CD28 Protein(KMP2380) is produced in HEK293 Cells and the target gene encoding Asn19-Pro152 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD28
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 150mM NaCl, pH8.0
Background	T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Predicted Molecular Weight	15.15 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	A8K632

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