Mouse CD137 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse CD137 Protein, Fc Tag

Mouse CD137 Protein, Fc Tag

产品编号

KMP2373

别名

肿瘤坏死因子超家族受体9, CD137, ILA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子超家族受体9, CD137, ILA
Catalog Number	KMP2373
Product Description	The Mouse CD137 Protein(KMP2373) is produced in HEK293 Cells and the target gene encoding Val24-Leu187 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD137
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, pH7.4
Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor(TNF) receptor family. It can be induced by lymphocyte activation(ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
Predicted Molecular Weight	17.4 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P20334
Function	Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8+ T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (By similarity).

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