Mouse CD273 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse CD273 Protein, Fc Tag

Mouse CD273 Protein, Fc Tag

产品编号

KMP2366

别名

程序性细胞死亡 1 配体 2, Programmed Cell Death 1 Ligand 2, CD273

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性细胞死亡 1 配体 2, Programmed Cell Death 1 Ligand 2, CD273
Catalog Number	KMP2366
Product Description	The Mouse CD273 Protein(KMP2366) is produced in HEK293 Cells and the target gene encoding Leu20-Arg219 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD273
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, pH7.4
Background	Programmed cell death 1 ligand 2(PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids(aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region, a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
SDS-PAGE
Predicted Molecular Weight	22.54 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q80WM9#structure
References	1.Nat. Immunol. 2:261-268 (2001) 2.J. Exp. Med. 193:839-846 (2001) 3.J. Exp. Med. 197:1083-1091 (2003)
Function	Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

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