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Human CD40L Protein

Human CD40L Protein

产品编号

KMP2359

别名

肿瘤坏死因子相关激活蛋白, Tumor Necrosis Factor Ligand Superfamily Member 5, CD154

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias肿瘤坏死因子相关激活蛋白, Tumor Necrosis Factor Ligand Superfamily Member 5, CD154
Catalog NumberKMP2359
Product DescriptionThe Human CD40L Protein(KMP2359) is produced in E.coli and the target gene encoding Met113-Leu261 is expressed.
Molecular NameCD40L
SpeciesHuman
HostE. coli
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
Formulation20mM PB, 200mM NaCl, 0.1mM EDTA, pH7.0
BackgroundCD40 Ligand(CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
SDS-PAGE
Predicted Molecular Weight16.19 kDa
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot IDC1L3E0
FunctionCytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.

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