Mouse CD276 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD276 Protein, His Tag

Mouse CD276 Protein, His Tag

产品编号

KMP2348

别名

共刺激分子蛋白, CD276 antigen, CD276, B7 homolog 3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	共刺激分子蛋白, CD276 antigen, CD276, B7 homolog 3
Catalog Number	KMP2348
Product Description	The Mouse CD276 Protein(KMP2348) is produced in HEK293 Cells and the target gene encoding Val29-Phe244 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD276
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
SDS-PAGE
Predicted Molecular Weight	24.32 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q8VE98
References	1.J. Immunol. 168:6294-6297 (2002) 2.Nat. Immunol. 4:899-906 (2003) 3.Gene Ther. 10:1728-1734 (2003) 4.J. Immunol. 173:2500-2506 (2004) 5.Eur. J. Immunol. 35:428-438 (2005)
Function	Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.

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